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Cellulose Acting as a Catalyst for Dissolution Modified Sodium Carboxy Methyl Cellulose Crosslinked Sodium Carboxy Methyl Cellulose. Introduction As importance of bio-availability and fast disintegration of pharmaceutical tablet is realised, awarness for super-disintegrants in pharmaceutical tablet formulation is also increasing . Superdisintegrant viz. Sodium Starch Glycollate was also introduced by Maple Biotech Pvt Ltd. in year 1991, which was appreciated in quality and performance by pharmaceutical industry . Although quest for superior quality superdisintegrant was not over . Superdisintegrant with better stability and superior performance at high tablet hardness level was sought and Maple Biotech's R & D department developed the product Crosslinked Sodium Carboxy Methyl Cellulose which is bearing brand name Cel-Ca-Dissol. Properties : Cel-Ca-Dissol is white or creamish white in colour and chemically it is cross-linked Sodium Carboxy Methyl Cellulose with very high degree of purity . Very hard tablets where other superdisintegrants do not perform well Cel-Ca-Dissol performs very much satisfactorily. Quantity to be used in pharmaceutical formulation is very less. Cel-Ca-Dissol is required almost half the amount of other brands of Crosslinked Sodium Carboxy Methyl Cellulose to acheive similiar performance of tablet dissolution Advantages of Croscarmellose Sodium good water uptake high capillary action rapid swelling properties efficient fluid channeling compatibility with most actives and excipients excellent long-term stability low usage level low cost-in-use very fast drug dissolution
Specifications of Cel-Ca-Dissol
|Sodium Chloride & Sodium Glycollate||Max. 0.5 %|
|pH ( 1% aqueous dispersion )||5.0 to 7.0|
|Heavy Metals||Max 10 ppm .|
|Sulphated Ash||14 to 28 %|
|Settling Volume (1.5 gm. in 100 ml.)||10 to 30 ml.|